Is Mpox Here to Stay? CDC Study Says Virus is Likely Becoming Endemic

Mpox is continuing to spread at low levels in the United States, suggesting the virus may be transitioning toward endemic circulation rather than remaining linked primarily to travel.

In 2024 and 2025, 76% of U.S. mpox cases occurred among unvaccinated people, who were nearly 10 times more likely to be hospitalized than those who received both Jynneos vaccine doses. Mpox remains most common among men who have sex with men, while transmission can occur through close contact, including within households.

The findings highlight the importance of vaccination for people at increased risk and ongoing monitoring of transmission. Read more from CIDRAP here.